63, 8998. Estimation of elemental concentrations of Indian medicinal plants using Energy dispersive X-ray fluorescence (EDXRF). An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. J. Pharm. (2014). Sci. Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. These toxicological studies, therefore, confirmed that the administration of CP is safe for the vital organs within the respective treatment durations. A brain tonic imbued with potent Medhya traits, Shankhpushpi is highly significant in dealing with hysteria as it effectively works as a stimulant and boosts the function of the brain. Integr. Herb. Lower sleep quality and variability in night .. Sage, known by various names - common sage, garden sage, kitchen sage, true sage.. Bhringaraj, popularly known as false daisy in English is a traditi.. Boil 1 teaspoon of shankhpushpi powder with a cup of water. In Indian medicinal system Ayurveda it is named as Shankhpushpi. doi:10.4103/0110-5558.76437, Sethiya, N. K., Raja, M. M. M., Mishra, S. H. (2013). 30, 578582. Prod. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Planta Med. India: iloveindia.com; 2013. Screening of anti-inflammatory and anti-analgesic activity of Convolvulus pluricaulis choisy. Chem. (2006). Learning behavior and memory enhancement activity, 100 mg/kg/passive avoidance paradigms and active avoidance test, 200 mg/kg/passive avoidance paradigms and active avoidance test. Indian J. Pharmacol. 1, 388395. The result shown that higher retension was observed with plant extract as compared with standard drug. Pharmacol. 3, 8183. Database on medicinal plants used in Ayurveda (Vol. Exams are around the corner and these are stressful times for both children and .. Senior citizens, please take note. Chem. But mostly it is used in the form of syrup. Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors. Federal government websites often end in .gov or .mil. The extensive health benefits of the various herbs used in this formulation also increase its therapeutic efficacy in treating infertility issues. Known as Mangalyakushuma in Sanskrit which means bringer of good fortune and health, each and every part of this milky-white flowered plant is extremely beneficial for treating a host of ailments and improving the longevity of life. Additionally, the presence of vitamin E in this herb also aids in controlling the levels of protein oxidation and lipid peroxidation, thereby leading to an escalation in the antioxidant defense system (Cowan, 1999; Nasri etal., 2015; Domnguez-Avila etal., 2016; Foretz etal., 2018). 95, 115122. Also Read: Introduction To Ayurveda: Learn About Vata, Pitta And Kapha Doshas. A chemical study of this plant was then initiated, which led to the isolation of carbohydrats, proteins, alkaloids, fatty acids, steroids, coumarins, flavanoids, and glycosides as active chemicals that bring about its biological effects. Kulkarni, R., Girish, K. J., Kumar, A. Sci. Science 330, 198198. 5, 959964. Established by the Indian Academy of Pediatrics Diarrheal diseases, Oral Rehydra.. Neurosci. The preliminary phytochemical screening carried out on ethanolic extracts of C. pluricaulis (leaves) revealed the presence of phytoconstituents such as alkaloids, glycosides, flavonoids, carbohydrates, proteins, sterols, gum and mucilages compounds. The natural plant products have negligible toxicities, if any, and are endowed with a multitude of phytoconstituents which are responsible for their holistic therapeutic action. Euphytica 147, 451460. WHO guided real time stability testing on Shankhpushpi Syrup. (2009). Dhingra, D., Valecha, R. (2007). These include Evolvulus alsinoides Linn, Clitoria ternatea Linn and Canscora decussata Schult. Indian J. Physiol. In the last few years, there has been an exponential growth in the field of herbal medicine, and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects[1]. In a study, Rawat and Kothiyal have also found that the aquo-methanolic, ethanolic and petroleum ether extracts isolated from CP (50400 mg/Kg) exhibited anxiolytic, memory-enhancing and nootropic activity as evaluated by using Elevated Plus Maze (EPM) and step-down models in mice. -Sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. The plant improves the balance and vitiation in kapha-vata-pitta doshas, and the herb is astringent and bitter[11]. Drinking a spoonful of shankhpushpi powder mixed in a glass of milk and Jeera, before going to sleep is highly effective in regulating body metabolism, inducing sleep and treating sleep disorders like insomnia. neurotransmitters and ups the secretion of dopamine which in turn keeps the serotonin level under control and helps to reduce various symptoms of anxiety which includes restlessness, uneasiness, cold hands, and feet, and helps in relaxing the mind and body. Hydroxycinnamic acids (HCAS): Structure, biological properties and health effects, in Advances in Medicine and Biology. CP plant also contains other alkaloids (convolamine, convosine, convoline, convolidine, convolvine, confoline, evolvine, phyllabine, subhirsine, sankhpuspine) (Agarwa etal., 2014; Balaji etal., 2014); anthroquinones; carbohydrates (D-glucose, sucrose, rhamnose, maltose) (Dhingra and Valecha, 2007; Bhowmik etal., 2012; Agarwa etal., 2014); coumarins (ayapanin, scopolin, scopoletin); flavonoids (kaempferol, quercetin) (Lal, 2014); glycosides (geranilan-3-ol-1-carboxylate-1-O--D-xylopyranosyl-(21)-O--D-xylopyranoside (Sultana etal., 2018); phenolic compounds; steroids; tannins; and terpenoids (Ravichandra etal., 2013; Agarwa etal., 2014; Balaji etal., 2014; Malik etal., 2016). Together this preparation assists in enhancing hair growth. C. pluricaulis is of various medicinal uses. (B) Main mechanisms and phytoconstituents responsible for neuro-pharmacological activities of C. prostratus (CP). doi:10.1007/s10600-013-0459-6. doi: 10.2174/187152809788681029, Ravichandra, V. D., Ramesh, C., Sridhar, K. A. The digestive properties found in this traditional herb is found to be extremely beneficial in improving digestion. The powerful combination of shankhpusphi and Brahmi in the syrup functions as an amazing brain stimulant. Res. Rev. Shankhapushpi holds high significance due to its potent anti-stress, anti-depressive and anti-anxiety properties are extremely useful for treating different types of psychotic problems like depression, dementia, restlessness, etc. These are reported to contain several types of alkaloids, flavanoids, and coumarins as active chemicals that bring about its biological effects[5]. Studies on medicinal properties of Convolvulus pluricaulis and Boerhaavia diffusa. (1999). Medicinal plants: chemistry and properties, (Boca Raton, Florida, United States: CRC press). 11, 31. doi:10.1186/s13002-015-0018-2, Malik, J., Karan, M., Vasisht, K. (2016). B., Prasad, S., Reuter, S., Kannappan, R., R Yadav, V., Park, B., et al. Moreover, it is employed in a variety of formulations used for the treatment of nervous disorders, such as insanity, epilepsy, hysteria, insomnia, and psycho-neurosis (Khare, 2004). In addition, CP is known to be a good source of vitamins and minerals, namely, calcium, copper, iron, magnesium, manganese, phosphorus, potassium, sulphur, zinc, vitamin C and E (Sethiya etal., 2010; Babu etal., 2015). 26, 868875. Pharm. Review of sankhahauli (Convolvulus pluricaulis choisy) from traditional medicine to modern science. Preliminary microscopical characters of ethanolic extracts of C. pluricaulis (leaves) are given in Table 3[13]. Although these plants proved their scientific potential in central nervous system depression, anxiolytic, tranquillizing, antidepressant, antistress, neurodegenerative, antiamnesic, antioxidant, hypolipidemic, immunomodulatory, analgesic, antifungal, antibacterial, antidiabetic, antiulcer, anticatatonic, and cardiovascular activity. Although you might be familiar with the statement, "you are what you eat", the f.. Convolvine also aids in potentiating the effect of another muscarinic memory enhancer, namely, arecoline, thereby imparting nootropic abilities to CP (Sethiya etal., 2009). 8600 Rockville Pike It is a good source of literature survey for researchers who intended to do studies in this particular field, and use this plant. AB and AV provided critical revision of this review article, and approved the manuscript for submission. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: reverse pharmacology and bedside to bench approach. The https:// ensures that you are connecting to the The bioactive constituents like the ethanolic extract reduce the levels of non-esterified fatty acids i.e. (2015). and transmitted securely. Rev. Bhowmik D, Kumar KPS, Paswan S, Srivatava S, Yadav A, Dutta A. Hence, these CP phyto-constituents ultimately aid in ameliorating the neuronal pain and headache (Aleebrahim-Dehkordy etal., 2017). J. Environ. Pharmacological and biochemical evidence for the antidepressant effect of the herbal preparation Trans-01. Shankapushpi. 2018, 5751864. doi:10.1155/2018/5751864, Keywords: Convolvulus prostratus, Shankhpushpi, natural product, Ayurveda, neuroprotective, nootropic, Citation: Balkrishna A, Thakur P and Varshney A (2020) Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies. The chemotherapeutic moieties used currently for the treatment of neurological disorders face a daunting challenge of systemic delivery of the drugs to the central nervous system. Pharm. Pharm. doi:10.1016/j.freeradbiomed.2015.01.018, Wei, C. X., Bian, M., Gong, G. H. (2015). In-Vitro Evaluation of Antioxidant Activity and Total Phenolic Content of Methanolic Extract of Convolvulus pluricaulis. Biol. CP extract also posed evident anti-oxidant activity and elevated the levels of glutathione reductase, superoxide dismutase and reduced glutathione within the cortex and hippocampus (Kaushik, 2017). The polyphenols present in this species act as reactive oxygen species (ROS) quenchers, thereby ameliorating the oxidative stress that is generated as a diabetic manifestation. FOIA Curr. (2018). Shankhpushpi works as an amazing natural remedy for hypertension treatment. Compd. 8, 1114. Phytochem. doi:10.1007/s12010-012-9791-8, Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., et al. Current Limitations in the Treatment of Parkinson's and Alzheimer's Diseases: State-of-the-Art and Future Perspective of Polymeric Carriers. It is highly beneficial in treating mental issues, forgetfulness and poor concentration. EPM test has mainly been used to investigate the interactions between aversive memory and anxiety responses of the mice. (2011). It also prevents fluid retention and treats symptoms of abdominal pain, abdominal distension, ulcerative colitis, and irritable bowel syndrome. Dev, S. (2006). Your moods, emotions and true feelings. Med. Bio. Microbiol. Several research teams across the globe have highlighted the neuro-pharmacological profile of C. prostratus, wherein, the neuroprotective, nootropic and neuro-modulatory roles have been described. Learn more Gogte, V. M. (2012). The author cited different papers in his manuscript to support the therapeutic potential of C. pluricaulis in traditional medicine. J. Pharmacogn. This paper covers the literature, primarily pharmacological, from 1985 to the end of 2012. 11:171. doi: 10.3389/fphar.2020.00171. doi:10.1016/S2221-1691(14)60240-9, Agarwal, P., Sharma, B., Alok, S. (2014). There are many kashayams, gutikas and churnas available in the market, that have the above combination and do not cause any counter interaction. This medicinal herb has been reported to contain many bioactive phytoconstituents, such as, alkaloid (convolamine), flavonoid (kaempferol) and phenolics (scopoletin, -sitosterol and ceryl alcohol), that have been ascribed to the observed medicinal properties. Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. Available at https://www.ijser.org/paper/Estimation-of-elemental-concentrations-of-Indian-medicinal-plants-using-Energy-dispersive-X-ray-fluorescence.html, Balaji, K., Hean, K. C., Ravichandran, K., Shikarwar, M. (2014). Aust. Moreover, the CP powder and juice, such as, Jain Shankhpushpi Powder and Axiom Jeevan Ras Shankhpushpi Juice, are also being used as skin mask for rejuvenating the skin and managing skin problems such as acne, blemishes and sun spots (Hindu, 2012). Int. But let us move on..