Iprovalicarb, a new anti downy mildew fungicide on grapevine. endstream
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Moreover it presents a new chemical mode of action, not totally identified, which is different from all the other products use on oomycetes. startxref
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Iprovalicarb is registered in France in three different ready-to-use mixtures (with mancozeb, folpet and copper) on downy mildew and Phomopsis viticola on vine. It is non-persistent in soil but may persist in water for a long time. trailer
Therefore, the entire F1 generation of crosses between sensitive and CAA resistant isolates was sensitive, and only in the F2 progeny did CAA resistance reappear in some isolates.
FAX: +49 621 60-27176 Uptake studies with 14C labelled Mandipropamid (MPD) showed that this Oomycete control agent acts on the cell wall and does not enter the cell. A carbamate/valinamide fungicide often used to control Oomycete pathogens, EC Regulation 1107/2009 (repealing 91/414), Approved for use () under EC 1107/2009 in the following EU Member States. 32 7
Both mutations in thePiCesA3gene result in a change to the same amino acid (Glycine-1105) in the protein. It is considered to be a carcinogen. +49 621 60-27299 2007) showed that sexual crosses between sensitive and CAA resistant isolates ofPlasmopara viticolalead to a co-segregation of resistance to dimethomorph, iprovalicarb, benthiavalicarb and mandipropamid, but not to the phenylamide, mefenoxam, which was tested in parallel as an independent marker. !XzCks0\B72B 7 gerd.stammler@basf.com. 2 0 obj
Low to medium risk. endobj
67117 Limburgerhof It is moderately toxic to mammals but has a low risk of bioaccumulating. J80@IGdlqK
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It is moderately toxic to birds, most aquatic organisms and earthworms but is not toxic to honeybees. Cellulose synthesis inhibitor. Sauzay, S. ((Bayer CropScience, Puteaux (France). /
R}}Jx!'{&}^~q(^?u|?`v!w3f7?=Pg"%?|T2]D}=y}?I6?8B#*Xt5M eo J;Ti@9 ?B'Q="[iX%F}.F@ vIF;rDUUKS NxLhC;FT^WV5(HM?G5ihl6v{czfq]~Dlx/7$cMA0t0)D3t54:Hi$;Uvhl$!! AanqONEqeh o{ CC1=CC=C(C=C1)C(C)NC(=O)C(C(C)C)NC(=O)OC(C)C, CC1=CC=C(C=C1)C(C)NC(=O)[C@H](C(C)C)NC(=O)OC(C)C, International Chemical Identifier key (InChIKey), International Chemical Identifier (InChI), InChI=1S/C18H28N2O3/c1-11(2)16(20-18(22)23-12(3)4)17(21)19-14(6)15-9-7-13(5)8-10-15/h7-12,14,16H,1-6H3,(H,19,21)(H,20,22)/t14?,16-/m0/s1/f/h19-20H, Cambridge Crystallographic Data Centre diagrams, Carbamate fungicide; Valinamide fungicide. isopropyl 2-methyl-1-{[(RS)-1-p-tolylethyl]carbamoyl}-(S)-propylcarbamate, 1-methylethyl ((1S)-2-methyl-1-(((1-(4-methylphenyl)ethyl)amino)carbonyl)propyl)carbamate, Relevant Environmental Water Quality Standards, Herbicide Resistance Classification (HRAC), Herbicide Resistance Classification (WSSA), Insecticide Resistance Classification (IRAC), Fungicide Resistance Classification (FRAC), Example manufacturers & suppliers of products using this active now or historically, Source; quality score; and other information, Solubility - In organic solvents at 20 C (mg l), Octanol-water partition coefficient at pH 7, 20 C, Henry's law constant at 25 C (Pa m mol), EU dossier lab studies DT range 20-30 days, field studies DT range 4.7-27 days, Dissipation rate RL on and in plant matrix, Published literature RL range 1.75-72.0 days, 2 field & undercover grown crops, various matrices, n=5, Aqueous hydrolysis DT (days) at 20 C and pH 7, SCI-GROW groundwater index (g l) for a 1 kg ha or 1 l ha application rate, Potential for particle bound transport index, Mammals - Chronic 21d NOAEL (mg kg bw d), Birds - Chronic 21d NOEL (mg kg bw d), Earthworms - Chronic NOEC, reproduction (mg kg), Nitrogen mineralisation: No significant adverse effect, Contact acute LD (worst case from 24, 48 and 72 hour values - g bee), Oral acute LD (worst case from 24, 48 and 72 hour values - g bee), Unknown mode acute LD (worst case from 24, 48 and 72 hour values - g bee), Acute LD (worst case from 24, 48 and 72 hour values - g insect), Beneficial insects (Parasitic wasps) as % Mortality at dose 0.46 kg ha, Beneficial insects (Predatory mites) as % Mortality at dose 0.46 kg ha, Aquatic invertebrates - Acute 48 hour EC (mg l), Aquatic invertebrates - Chronic 21 day NOEC (mg l), Aquatic crustaceans - Acute 96 hour LC (mg l), Sediment dwelling organisms - Acute 96 hour LC (mg l), Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l), Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg), Aquatic plants - Acute 7 day EC, biomass (mg l), Algae - Acute 72 hour EC, growth (mg l), Algae - Chronic 96 hour NOEC, growth (mg l), Threshold of Toxicological Concern (Cramer Class), Mammals - Dermal LD (mg kg body weight), ADI - Acceptable Daily Intake (mg kg bw day), ARfD - Acute Reference Dose (mg kg bw day), AAOEL - Acute Acceptable Operator Exposure Level (mg kg bw day), AOEL - Acceptable Operator Exposure Level - Systemic (mg kg bw day), No unacceptable risks to bystanders identified, No unacceptable risks to operators or other workers identified, Mammalian dose elimination route and rate. Sensitivity monitoring studies over several years revealed that in populations of the late blight pathogen,Phytophthora infestans, all isolates were fully sensitive to CAA fungicides. Premier institut de recherche agronomique en Europe, deuxime dans le monde, l'Inra mne des recherches finalises pour une alimentation saine et de qualit, pour une agriculture comptitive et durable, et pour un environnement prserv et valoris. Resistance management required. 0
The ratio of these two diastereoisomers A(S,R) and B(S,S) in technical material is approximately 1:1. Sauzay, S.; Wartelle, D.; Brillant, G.; Pichon, F. Iprovalicarb is a new oomycete fungicide developped specifically by Bayer CropScience France. 2560 The mode of action of CAA compounds is directly linked to the inhibition of cellulose synthesis in the Oomycete plant pathogen (Blum et al. 0000002148 00000 n
40 in the FRAC Code List. Iprovalicarb is a mixture of two diastereoisomers, each consisting of only one enantiomer. Systemic with protective, curative and eradicative action. 0000000849 00000 n
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FRAC-Recommendations for Resistance Management for CAA Fungicides. <>/XObject<>/ExtGState<>/Pattern<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 14 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>
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and cell wall deposition (proposed). Inheritance studies (Gisi et al. Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. %%EOF
Go directly to FRAC-Recommendations for Resistance Management for CAA Fungicides. A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid inPlasmopara viticola. All of the above-mentioned fungicides exhibit cross resistance and are grouped under the FRAC Code No. @P6#91hdw4J,E@;6yCh,tmX">;1@$aDdt8DtC\W) Further, the inheritance studies showed that the gene(s) for resistance to CAA fungicides are inherited in a recessive manner. %
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However, in populations of the grape downy mildew pathogen,Plasmopara viticola, isolates can be found in certain regions, which are resistant to all CAA fungicides. 38 0 obj
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300/1 As shown in the table, the group nameCarboxylicAcidAmides (CAA) has been chosen. These results suggest that the resistance risk can be classified as moderate (as compared to high for phenylamide and QoI fungicides) and that it can be managed by appropriate product use strategies. Vm%q#j@@piGl,qu+$Q J-{VSAvT8AAW(RDp!E x=ksj\ `0Rc:x$ueDA"lPHP@urYKw/6Uq+lo/?>*W 2 It has a low aqueous solubility, is semi-volatile and there is some risk it may leach to groundwater. 4 q Thanks to its very favourable toxicological and environmental profile, Iprovalicarb can easily be used in an integrated pest management program, [Phytoma. Iprovalicarb is the single active ingredient of a new chemical family: the amino acid amid carbamates. Pandora, Demetra, A = Chromosome aberration (EFSA database), E = Unspecified genotoxicity type (miscellaneous data source). All the trials show that Iprovalicarb control with high efficiency the downy mildew both on leaves and bunches. EU Annex III PIC DGD) (, R = Peer reviewed scientific publications, K = Research datasets, e.g. Iprovalicarb is a systemic, protectant fungicide. Iprovalicarb presents a high protective activity but also a curative and antisporulant activity on downy mildew. VisionShape Compression Software, Version 2.5 (2016) An international database for pesticide risk assessments and management. 32 0 obj
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{W`K`c`[. Fongicide antimildiou vigne"@fra. Iprovalicarb is thus an ideal partner for an anti-resistance strategy. La Dfense des Vgtaux (France)], "Iprovalicarb, a new anti downy mildew fungicide on grapevine"@eng, "L'iprovalicarb. i(Cap?D}4qyJJSHDDr6R APR/FM - LI470, BASF SE <<2FE76313CA2C994F8C7A130558EF7175>]>>
0 This name best represents compounds from the three different chemical groups. 1 0 obj
Blum M, Waldner M, Gisi U. 2010). Fungal Genetics and Biology 2010;47(6):499-510. A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. The following alerts are based on the data in the tables below. endobj
The FRAC CAA Working Group was set up in 2005 to generate common resistance management recommendations for the Oomycete fungicides dimethomorph, flumorph, iprovalicarb, benthiavalicarb, mandipropamid and valifenalate. 1 %PDF-1.5
Gene sequence analysis of cellulose synthase genes in laboratory mutants, insensitive to MPD, revealed two point mutations in thePiCesA3gene. <>
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phospholipid biosynthesis
@H$#l An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. A molecule with 2 chiral centres. Germany, Tel. endstream
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This gene is known to be involved in cellulose synthesis. xb```a`` 6 a0pxl>t]Oin00@1@N u@ n
Furthermore, 14C glucose incorporation into cellulose was perturbed in the presence of MPD. <>
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